2'-Fluoro-2-(1-fluoro-3,3-dimethylbutyl)-5'-methoxy-4-((4-methoxybenzyl)oxy)biphenyl → 2'-Fluoro-2-(1-fluoro-3,3-dimethylbutyl)-5'-methoxybiphenyl-4-ol

Participants

Reaction Conditions

Reaction Steps

To a solution of 2′-fluoro-2-(1-fluoro-3,3-dimethylbutyl)-5′-methoxy-4-((4-methoxybenzyl)oxy)biphenyl (120 mg) in methanol (5 mL) was added 10% palladium-carbon (100 mg) and, under a hydrogen atmosphere, the mixture was stirred at 70° C. for 17 hr. The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure to give a crude product of the title compound as a colorless oil. This compound was used for the next step without further purification.

Provenance & Evidence