1-methyl-1H-imidazole-2-carboxylic acid → HCID 117699159, compound

HRID 1049704Notes

Reaction equation

HRID 1049704 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([OH:9])=O.[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[C:23](=[O:24])[CH2:22][C:21](=[O:25])[NH:20][C:19]3[C:26]4[C:31]([CH:32]=[CH:33][C:18]2=3)=[CH:30][CH:29]=[CH:28][CH:27]=4)=[CH:13][CH:12]=1.CN1C=CN=C1C(Cl)=O>>[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[C:23](=[O:24])[CH2:22][C:21](=[O:25])[NH:20][C:19]3[C:26]4[C:31]([CH:32]=[CH:33][C:18]2=3)=[CH:30][CH:29]=[CH:28][CH:27]=4)=[CH:13][CH:12]=1)=[O:9]

Participants

4

Reactant 3

HCID 5576781-methyl-1H-imidazole-2-carboxylic acidHCID 226467521-Methyl-1H-imidazole-2-carbonyl chlorideHCID 1176991675-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

Product 1

HCID 117699159HCID 117699159, compoundYield 13.4%

Procedure

1-Methyl-1H-imidazole-2-carboxylic acid (40 mg, 0.317 mmol) was made into acid chloride in a conventional manner. By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (50 mg, 0.158 mmol) obtained in Example 1, (3), and 1-methyl-1H-imidazole-2-carboxylic acid chloride mentioned above, the title compound (9 mg, yield 13%) was obtained in the same manner as that of Example 1.

Sources & evidence

ORD record
ord-2ae9133a1f0840bfb760ee362ebd0d36
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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