2,3-Dimethylbenzoic acid → HCID 117699240, compound

HRID 1049722Notes

Reaction equation

HRID 1049722 reaction equation
[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[C:29]([CH3:30])[C:24]=3[NH:23][C:22](=[O:31])[CH2:21][C:20]2=[O:32])=[CH:15][CH:14]=1.CC1C(C)=CC=CC=1C(Cl)=O>>[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[C:29]([CH3:30])[C:24]=3[NH:23][C:22](=[O:31])[CH2:21][C:20]2=[O:32])=[CH:15][CH:14]=1)=[O:6]

Participants

4

Reactant 3

HCID 117822,3-Dimethylbenzoic acidHCID 28008992,3-Dimethylbenzoyl chlorideHCID 117699136HCID 117699136, compound

Product 1

HCID 117699240HCID 117699240, compoundYield 92%

Procedure

2,3-Dimethylbenzoic acid (21 mg, 0.140 mmol) was made into acid chloride in a conventional manner. By using 1-(4-aminophenyl)-6-methyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione (20 mg, 0.071 mmol) mentioned above, and 2,3-dimethylbenzoyl chloride mentioned above, the title compound (27 mg, yield 92%) was obtained in the same manner as that of Example 1.

Sources & evidence

ORD record
ord-76eec9d5d57b437a819c53bffe340acb
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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