2-Iodobenzoic acid → HCID 117720140, compound

HRID 1049737Notes

Reaction equation

HRID 1049737 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.CC1C(C)=CC=CC=1C([NH:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[C:33]([CH3:34])[C:28]=3[NH:27][C:26](=[O:35])[CH2:25][C:24]2=[O:36])=[CH:19][CH:18]=1)=O.I[C:43]1C=CC=CC=1C(Cl)=O>>[CH3:34][C:33]1[C:28]2[NH:27][C:26](=[O:35])[CH2:25][C:24](=[O:36])[N:23]([C:20]3[CH:19]=[CH:18][C:17]([NH:16][C:4](=[O:6])[C:3]4[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=4[I:1])=[CH:22][CH:21]=3)[C:29]=2[CH:30]=[CH:31][C:32]=1[CH3:43]

Participants

4

Reactant 3

HCID 69412-Iodobenzoic acidHCID 691122-Iodobenzoyl chlorideHCID 117699240HCID 117699240, compound

Product 1

HCID 117720140HCID 117720140, compoundYield 87%

Procedure

2-Iodobenzoic acid (34 mg, 0.137 mmol) was made into acid chloride in a conventional manner. By using 1-(4-aminophenyl)-6,7-dimethyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione (20 mg, 0.068 mmol) obtained in Example 56, and 2-iodobenzoyl chloride mentioned above, the title compound (31 mg, yield 87%) was obtained in the same manner as that of Example 1.

Sources & evidence

ORD record
ord-a3119bd403454e06b27dd1df811dc6a1
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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