m-Bromobenzenesulphonyl chloride → 3-Bromo-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepin-5-yl)phenyl]benzenesulfonamide

HRID 1049808ノート

反応式

HRID 1049808 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[CH2:18][CH2:19][CH2:20][CH2:21][C:22]=4[CH:23]=[CH:24][C:9]2=3)=[CH:4][CH:3]=1.[Br:25][C:26]1[CH:27]=[C:28]([S:32](Cl)(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1>N1C=CC=CC=1>[Br:25][C:26]1[CH:27]=[C:28]([S:32]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([N:8]3[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]4[C:17]5[CH2:18][CH2:19][CH2:20][CH2:21][C:22]=5[CH:23]=[CH:24][C:9]3=4)=[CH:6][CH:7]=2)(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1

参加物

4

反応物 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 866893185-(4-Aminophenyl)-1,5,8,9,10,11-hexahydronaphtho[1,2-b][1,4]diazepine-2,4-dione

生成物 1

HCID 1176991753-Bromo-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepin-5-yl)phenyl]benzenesulfonamide収率 43%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5-(4-Aminophenyl)-1,5,8,9,10,11-hexahydronaphtho[1,2-b][1,4]diazepine-2,4-dione (65 mg, 202 mmol) obtained in Example 55, and 3-bromobenzenesulfonyl chloride (78 mg, 0.305 mmol) were treated by heating in pyridine (2.0 mL). After the disappearance of the starting materials was confirmed, the same treatment as that of Example 145 was performed to obtain the title compound (47 mg, yield 43%) as white crystals.

出典と根拠

ORDレコード
ord-67baf180eba64ad8b84ce01e42e7c269
出典データセット
uspto-grants-2016_07
特許番号
US09382236B2

反応ノート

読み込み中…