(2-Chlorophenyl)methanesulfonyl chloride → HCID 117699045, compound

HRID 1049815Notes

Reaction equation

HRID 1049815 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14]3[CH:15]=[CH:16][C:17]([O:19][CH3:20])=[CH:18][C:13]=3[NH:12][C:11](=[O:21])[CH2:10][C:9]2=[O:22])=[CH:4][CH:3]=1.[Cl:23][C:24]1[CH:34]=[CH:33][CH:32]=[CH:31][C:25]=1[CH2:26][S:27](Cl)(=[O:29])=[O:28]>>[Cl:23][C:24]1[CH:34]=[CH:33][CH:32]=[CH:31][C:25]=1[CH2:26][S:27]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:9](=[O:22])[CH2:10][C:11](=[O:21])[NH:12][C:13]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]2=3)=[CH:4][CH:3]=1)(=[O:29])=[O:28]

Participants

3

Reactant 2

HCID 2757801(2-Chlorophenyl)methanesulfonyl chlorideHCID 117699460HCID 117699460, compound

Product 1

HCID 117699045HCID 117699045, compoundYield 21.5%

Procedure

By using 1-(4-aminophenyl)-7-methoxy-1H-1,5-benzodiazepine-2,4(3H,5H)-dione (65 mg, 0.22 mmol), and 2-chlorobenzylsulfonyl chloride (74 μL, 0.33 mmol), the title compound (23 mg, yield 13%) was obtained in the same manner as that of Example 145.

Sources & evidence

ORD record
ord-8f68296e0f4a4972aa46a0af3c1afd0c
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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