4-Chloro-5-fluoro-7H-pyrrolo(2,3-d)pyrimidine → 6-[(5-Fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-5-methoxy-1,3-benzothiazol-2(3H)-one

HRID 1049854Notes

Reaction equation

HRID 1049854 reaction equation
Cl[C:2]1[C:3]2[C:10]([F:11])=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:12][C:13]1[C:22]([O:23][CH3:24])=[CH:21][C:16]2[NH:17][C:18](=[O:20])[S:19][C:15]=2[CH:14]=1>>[F:11][C:10]1[C:3]2[C:2]([NH:12][C:13]3[C:22]([O:23][CH3:24])=[CH:21][C:16]4[NH:17][C:18](=[O:20])[S:19][C:15]=4[CH:14]=3)=[N:7][CH:6]=[N:5][C:4]=2[NH:8][CH:9]=1

Participants

3

Reactant 2

HCID 113212244-Chloro-5-fluoro-7H-pyrrolo(2,3-d)pyrimidineHCID 900149486-amino-5-methoxy-1,3-benzothiazol-2(3H)-one

Product 1

HCID 733883706-[(5-Fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-5-methoxy-1,3-benzothiazol-2(3H)-one

Procedure

50 mg (291 μmol) 4-chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (CAS-No: 582313-57-3) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 2.9 mg (3%) of the title compound.

Workup

  1. customto give
  2. custompurification 2.9 mg (3%) of the title compound

Sources & evidence

ORD record
ord-9011cf2eb98f4997884899a978a36326
Source dataset
uspto-grants-2016_07
Patent number
US09382255B2

Reaction notes

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