Chlorosuccinimide → HCID 117703959, compound

Participants

Reaction Steps

2-acetylamino-thiophene-3-carboxylic acid amide (2.38 g, 12.9 mmol) is dissolved in AcOH (25 mL). NCS (1.9 g, 14.3 mmol) is added and the resulting suspension is stirred at room temperature. After overnight stirring, another 150 mg (1.13 mmol) of NCS is added to the mixture and stirring is continued at 35° C. for 3 h. The mixture is evaporated, and the resulting residue is suspended in water, sonicated, and filtered to give the desired product.

Provenance & Evidence