Chlorosuccinimide → HCID 117703959, compound

HRID 1049860Notes

Reaction equation

HRID 1049860 reaction equation
[C:1]([NH:4][C:5]1[S:6][CH:7]=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])(=[O:3])[CH3:2].C1C(=O)N([Cl:20])C(=O)C1>CC(O)=O>[C:1]([NH:4][C:5]1[S:6][C:7]([Cl:20])=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 31398Chlorosuccinimide2×HCID 6852048HCID 6852048, compound

Product 1

HCID 117703959HCID 117703959, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-acetylamino-thiophene-3-carboxylic acid amide (2.38 g, 12.9 mmol) is dissolved in AcOH (25 mL). NCS (1.9 g, 14.3 mmol) is added and the resulting suspension is stirred at room temperature. After overnight stirring, another 150 mg (1.13 mmol) of NCS is added to the mixture and stirring is continued at 35° C. for 3 h. The mixture is evaporated, and the resulting residue is suspended in water, sonicated, and filtered to give the desired product.

Workup

  1. stirringAfter overnight stirring
  2. stirringstirring
  3. customThe mixture is evaporated
  4. customsonicated
  5. filtrationfiltered

Sources & evidence

ORD record
ord-6abad1c457034893ae11f3a95e7963ba
Source dataset
uspto-grants-2016_07
Patent number
US09382254B2

Reaction notes

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