Chlorosuccinimide → [2-[(3-Carbamoyl-5-chloro-2-thienyl)amino]-1,1-dimethyl-2-oxo-ethyl]acetate

Participants

Reaction Steps

Intermediate 10 (78.5 g, 291 mmol) is dissolved in AcOH (850 mL). To the resulting suspension, NCS (42.9 g, 320 mmol) is added. The mixture is stirred at room temperature, after which it is evaporated to give a slurry. This slurry is taken up in water to give a suspension that is filtered. Resulting precipitate is dried in the vacuum oven and used as such.

Provenance & Evidence