Acetic Acid → HCID 178513510, compound

HRID 1049874Notes

Reaction equation

HRID 1049874 reaction equation
[C:1]([C:4]1[CH:8]=[CH:7][S:6][C:5]=1[NH:9][C:10]([C:12]1[CH:16]=[CH:15][NH:14][N:13]=1)=[O:11])(=[O:3])[NH2:2].CC(O)=O.C1C(=O)N([Br:28])C(=O)C1>C(Cl)Cl>[Br:28][C:7]1[S:6][C:5]([NH:9][C:10]([C:12]2[CH:16]=[CH:15][NH:14][N:13]=2)=[O:11])=[C:4]([C:1](=[O:3])[NH2:2])[CH:8]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 67184N-bromobutanimideHCID 178513700HCID 178513700, compound

Product 1

HCID 178513510HCID 178513510, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1H-Pyrazole-3-carboxylic acid (3-carbamoyl-thiophen-2-yl)-amide (355 mg, 1.5 mmol) is mixed with AcOH (5 mL). NBS (280 mg, 1.58 mmol) is then added and the mixture is stirred at room temperature overnight. Evaporation gives a residue that is subsequently dissolved in DCM, the resulting organic phase is washed with aqueous NaHCO3, dried over MgSO4, filtered and evaporated to give a residue that is used as such.

Workup

  1. customEvaporation
  2. customgives a residue that
  3. washthe resulting organic phase is washed with aqueous NaHCO3
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customevaporated
  7. customto give a residue that

Sources & evidence

ORD record
ord-0d9d121fc68a4e85a4b5664f23afe8d9
Source dataset
uspto-grants-2016_07
Patent number
US09382254B2

Reaction notes

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