HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1049879Generated: October 31, 2026
Hydrochloric Acid → HCID 117703997, compound
https://huagongshe.com/reaction/1049879
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 117717821 | HCID 117717821 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 117703997 | HCID 117703997 | — |
Reaction Steps
The acetic acid 1-[3-carbamoyl-5-(2-fluoro-4-trifluoromethyl-benzenesulfonyl)-thiophen-2-ylcarbamoyl]-1-methyl-ethyl ester (1.24 g, 2.5 mmol) is dissolved in 1,4-dioxane (35 mL) and an aqueous solution of 6 M HCl (25 mL). This mixture is stirred at 60° C. overnight, after which the mixture is evaporated. Purification by silica chromatography (EtOAc/hexane; 1:1) affords the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09382254B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-8357caa60cff428dbe53f1a138622ea3 |
|---|
| Source note | uspto-grants-2016_07 |
|---|
