Hydrochloric Acid → HCID 117703997, compound

HRID 1049879Notes

Reaction equation

HRID 1049879 reaction equation
[C:1]([C:4]1[CH:8]=[C:7]([S:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[F:22])(=[O:11])=[O:10])[S:6][C:5]=1[NH:23][C:24]([C:26]([O:29]C(=O)C)([CH3:28])[CH3:27])=[O:25])(=[O:3])[NH2:2].Cl>O1CCOCC1>[F:22][C:13]1[CH:14]=[C:15]([C:18]([F:21])([F:19])[F:20])[CH:16]=[CH:17][C:12]=1[S:9]([C:7]1[S:6][C:5]([NH:23][C:24](=[O:25])[C:26]([OH:29])([CH3:28])[CH3:27])=[C:4]([C:1]([NH2:2])=[O:3])[CH:8]=1)(=[O:10])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117717821HCID 117717821, compound

Product 1

HCID 117703997HCID 117703997, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

The acetic acid 1-[3-carbamoyl-5-(2-fluoro-4-trifluoromethyl-benzenesulfonyl)-thiophen-2-ylcarbamoyl]-1-methyl-ethyl ester (1.24 g, 2.5 mmol) is dissolved in 1,4-dioxane (35 mL) and an aqueous solution of 6 M HCl (25 mL). This mixture is stirred at 60° C. overnight, after which the mixture is evaporated. Purification by silica chromatography (EtOAc/hexane; 1:1) affords the desired compound.

Workup

  1. customafter which the mixture is evaporated
  2. customPurification by silica chromatography (EtOAc/hexane; 1:1)

Sources & evidence

ORD record
ord-8357caa60cff428dbe53f1a138622ea3
Source dataset
uspto-grants-2016_07
Patent number
US09382254B2

Reaction notes

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