Hydrazine, dihydrochloride → HCID 71269227, compound

HRID 1049972Notes

Reaction equation

HRID 1049972 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22]3[C:27]([C:28](OCC)=[O:29])=[C:26]([CH:33]=O)[N:25]=[C:24]([N:35]4[CH2:40][CH2:39][O:38][CH2:37][CH2:36]4)[N:23]=3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:41].Cl.[NH2:43][NH2:44]>C(O)C>[ClH:41].[O:38]1[CH2:37][CH2:36][N:35]([C:24]2[N:23]=[C:22]([NH:21][C:18]3[CH:19]=[CH:20][C:15]([CH2:14][N:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[CH:16][CH:17]=3)[C:27]3[C:28](=[O:29])[NH:44][N:43]=[CH:33][C:26]=3[N:25]=2)[CH2:40][CH2:39]1

Participants

4

Reactant 2

HCID 17548Hydrazine, dihydrochlorideHCID 86677024HCID 86677024, compound

Product 1

HCID 71269227HCID 71269227, compoundYield 59.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 4-(4-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenylamino)-6-formyl-2-morpholinopyrimidine-5-carboxylate (100 mg, 0.18 mmol) was dissolved in ethanol, hydrazine dihydrochloride (28 mg, 26 mmol) was added and the mixture was refluxed for 3 hours. The solid precipitated was filtered and dried in vacuum to give the desired product (49 mg).

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. customThe solid precipitated
  3. filtrationwas filtered
  4. customdried in vacuum

Sources & evidence

ORD record
ord-775d8e99eb5449199808ed5a8274783f
Source dataset
uspto-grants-2016_07
Patent number
US09382277B2

Reaction notes

Loading…