Pyridine → Hydrochloric Acid

HRID 105000Notes

Reaction equation

HRID 105000 reaction equation
[CH3:40][CH2:41][O:42][CH2:43][CH3:44].[Cl:45][CH2:46][Cl:47].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][CH:11]([C:23](=[O:24])[Cl:25])[N:12]2[S:13](=[O:14])(=[O:15])[c:16]2[cH:17][cH:18][c:19]([CH3:22])[cH:20][cH:21]2)[cH:6][cH:7]1.[cH:26]1[cH:27][cH:28][n:29][cH:30][cH:31]1.[cH:32]1[c:33]([CH2:38][NH2:39])[cH:34][cH:35][cH:36][n:37]1>>[ClH:25].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][CH:11]([C:23](=[O:24])[NH:39][CH2:38][c:33]3[cH:32][n:37][cH:36][cH:35][cH:34]3)[N:12]2[S:13](=[O:14])(=[O:15])[c:16]2[cH:17][cH:18][c:19]([CH3:22])[cH:20][cH:21]2)[cH:6][cH:7]1

Participants

7

Reactant 5

HCID 1049PyridineHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 310183-PyridinemethanamineHCID 22250428(2RS,5SR)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic chloride

Product 2

HCID 313Hydrochloric AcidHCID 865843675-(4-fluorophenyl)-1-(4-methylphenyl)sulfonyl-N-(pyridin-3-ylmethyl)pyrrolidine-2-carboxamide

Sources & evidence

ORD record
ord-90f187bd785645fd8917669ae2601eed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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