Phthalimide potassium salt → HCID 90295825, compound

HRID 1050203Notes

Reaction equation

HRID 1050203 reaction equation
[O:1]=[C:2]1[N:6]2[C:7]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:20][CH2:19][CH2:18][CH2:17][C:16]4=[O:21])=[CH:11][C:8]=3[O:9][CH2:10][C@H:5]2[C@@H:4]([CH2:22]CS([O-])(=O)=O)[O:3]1.[K].[C:29]1(=[O:39])[NH:33][C:32](=[O:34])[C:31]2=[CH:35][CH:36]=[CH:37][CH:38]=[C:30]12>>[O:1]=[C:2]1[N:6]2[C:7]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:20][CH2:19][CH2:18][CH2:17][C:16]4=[O:21])=[CH:11][C:8]=3[O:9][CH2:10][C@H:5]2[C@H:4]([CH2:22][N:33]2[C:29](=[O:39])[C:30]3[C:31](=[CH:35][CH:36]=[CH:37][CH:38]=3)[C:32]2=[O:34])[O:3]1

Participants

3

Reactant 2

HCID 24194345Phthalimide potassium saltHCID 131736050HCID 131736050, compound

Product 1

HCID 90295825HCID 90295825, compoundYield 79.4%

Procedure

Using compound ((3R,3aS)-1-oxo-7-(2-oxopiperidin-1-yl)-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl)methylmethanesulfonate (0.774 g, 1.95 mmol), phthalimide potassium (0.542 g, 2.93 mmol) as starting materials, preparation following the method as described in Example 1(d) afforded white solid 0.693 g, yield: 79.3%.

Workup

  1. custommaterials, preparation

Sources & evidence

ORD record
ord-88adb7126d70487d85699ee1ac08ee64
Source dataset
uspto-grants-2016_07
Patent number
US09382265B2

Reaction notes

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