Methanesulfonyl chloride → HCID 90295545, compound

HRID 1050215Notes

Reaction equation

HRID 1050215 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:18]=[CH:19][C:20]3[N:25]4[C:26](=[O:31])[O:27][C@@H:28]([CH2:29][OH:30])[C@@H:24]4[CH2:23][O:22][C:21]=3[CH:32]=2)[C:13](=[O:33])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34][S:35](Cl)(=[O:37])=[O:36]>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:18]=[CH:19][C:20]3[N:25]4[C:26](=[O:31])[O:27][C@@H:28]([CH2:29][O:30][S:35]([CH3:34])(=[O:37])=[O:36])[C@@H:24]4[CH2:23][O:22][C:21]=3[CH:32]=2)[C:13](=[O:33])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 90295763HCID 90295763, compound

Product 1

HCID 90295545HCID 90295545, compoundYield 82.52%

Procedure

Using compound 4-((3R,3 aS)-3-(hydroxymethyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-7-yl)-3-oxopiperazin-1-carboxylic acid benzyl ester (0.946 g, 2.088 mmol), methylsulfonyl chloride (0.359 g, 3.13 mmol), and TEA (0.422 g, 4.18 mmol) as starting materials, preparation following the method as described in Example 1 (c) afforded white solid 0.916 g, yield: 82.52%.

Workup

  1. custommaterials, preparation

Sources & evidence

ORD record
ord-796ea2e6311445adbab88c5aed1c33f0
Source dataset
uspto-grants-2016_07
Patent number
US09382265B2

Reaction notes

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