Phthalimide potassium salt → HCID 90295627, compound

HRID 1050216Notes

Reaction equation

HRID 1050216 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:18]=[CH:19][C:20]3[N:25]4[C:26](=[O:35])[O:27][C@@H:28]([CH2:29]OS(C)(=O)=O)[C@@H:24]4[CH2:23][O:22][C:21]=3[CH:36]=2)[C:13](=[O:37])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[K].[C:39]1(=[O:49])[NH:43][C:42](=[O:44])[C:41]2=[CH:45][CH:46]=[CH:47][CH:48]=[C:40]12>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:18]=[CH:19][C:20]3[N:25]4[C:26](=[O:35])[O:27][C@@H:28]([CH2:29][N:43]5[C:39](=[O:49])[C:40]6[C:41](=[CH:45][CH:46]=[CH:47][CH:48]=6)[C:42]5=[O:44])[C@@H:24]4[CH2:23][O:22][C:21]=3[CH:36]=2)[C:13](=[O:37])[CH2:12]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 24194345Phthalimide potassium saltHCID 90295545HCID 90295545, compound

Product 1

HCID 90295627HCID 90295627, compoundYield 79.1%

Procedure

Using compound 4-((3R,3 aS)-3-((methylsulfonyloxy)methyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-7-yl)-3-oxopiperazin-1-carboxylic acid benzyl ester (0.916 g, 1.725 mmol), and phthalimide potassium (0.479 g, 2.558 mmol) as starting materials, preparation following the method as described in Example 1 (d) afforded white solid 0.794 g, yield: 79.1%.

Workup

  1. custommaterials, preparation

Sources & evidence

ORD record
ord-bd86571d862344d0bdd0f0e26dce66e8
Source dataset
uspto-grants-2016_07
Patent number
US09382265B2

Reaction notes

Loading…