Phthalimide potassium salt → HCID 90295592, compound

HRID 1050230Notes

Reaction equation

HRID 1050230 reaction equation
O=C1N2C3C=CC(N4CCOCC4=O)=CC=3OC[C@@H]2[C@@H](CCS([O-])(=O)=O)O1.O([CH2:36][C@H:37]1[C@@H:45]2[N:40]([C:41]3[CH:49]=[CH:48][C:47]([N:50]4[CH2:55][CH2:54][O:53][CH2:52][C:51]4=[O:56])=[CH:46][C:42]=3[O:43][CH2:44]2)[C:39](=[O:57])[O:38]1)[Si](C(C)(C)C)(C)C.[K].[C:59]1(=[O:69])[NH:63][C:62](=[O:64])[C:61]2=[CH:65][CH:66]=[CH:67][CH:68]=[C:60]12>>[O:57]=[C:39]1[N:40]2[C:41]3[CH:49]=[CH:48][C:47]([N:50]4[CH2:55][CH2:54][O:53][CH2:52][C:51]4=[O:56])=[CH:46][C:42]=3[O:43][CH2:44][C@@H:45]2[C@H:37]([CH2:36][N:63]2[C:59](=[O:69])[C:60]3[C:61](=[CH:65][CH:66]=[CH:67][CH:68]=3)[C:62]2=[O:64])[O:38]1

Participants

4

Reactant 3

HCID 24194345Phthalimide potassium saltHCID 90295553HCID 90295553, compoundHCID 131736055HCID 131736055, compound

Product 1

HCID 90295592HCID 90295592, compoundYield 82.1%

Procedure

Using compound ((3R,3 aR)-1-oxo-7-(3-oxomorpholin-4-yl)-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl)methylmethanesulfonate (2.98 g, 7.48 mmol) prepared above in (a) and phthalimide potassium (2.08 g, 11.22 mmol) as starting materials, preparation following the method as described in Example 1 (d) afforded white solid 2.76 g, yield: 82.1%.

Workup

  1. custommaterials, preparation

Sources & evidence

ORD record
ord-2845f116079e4fe2a3b0ebcdfd0f2415
Source dataset
uspto-grants-2016_07
Patent number
US09382265B2

Reaction notes

Loading…