Hydrochloric Acid → HCID 118114426, compound

Participants

Reaction Steps

Compound 57 was treated with 4N HCl in dioxane (20 mL) at RT for 1 h. The mixture was concentrated in vacuo and the solid residue was triturated with MTBE (40 mL) at RT overnight. The solid was filtered, washed with MTBE and dried in vacuo to give (R)-6-cyclopropyl-8-fluoro-2-(piperidin-3-yl)isoquinolin-1(2H)-one hydrochloride (59) (51 mg).

Provenance & Evidence