Hydrochloric Acid → HCID 118114426, compound

HRID 1050506Notes

Reaction equation

HRID 1050506 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]3[C:11](=[C:12]([F:14])[CH:13]=2)[C:10](=[O:15])[N:9]([C@@H:16]2[CH2:21][CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17]2)[CH:8]=[CH:7]3)[CH2:3][CH2:2]1.[ClH:29]>O1CCOCC1>[ClH:29].[CH:1]1([C:4]2[CH:5]=[C:6]3[C:11](=[C:12]([F:14])[CH:13]=2)[C:10](=[O:15])[N:9]([C@@H:16]2[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]2)[CH:8]=[CH:7]3)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118115106HCID 118115106, compound

Product 1

HCID 118114426HCID 118114426, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Compound 57 was treated with 4N HCl in dioxane (20 mL) at RT for 1 h. The mixture was concentrated in vacuo and the solid residue was triturated with MTBE (40 mL) at RT overnight. The solid was filtered, washed with MTBE and dried in vacuo to give (R)-6-cyclopropyl-8-fluoro-2-(piperidin-3-yl)isoquinolin-1(2H)-one hydrochloride (59) (51 mg).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe solid residue was triturated with MTBE (40 mL) at RT overnight
  3. filtrationThe solid was filtered
  4. washwashed with MTBE
  5. customdried in vacuo

Sources & evidence

ORD record
ord-e57bb16463cf417a8b1f66987af99bfc
Source dataset
uspto-grants-2016_07
Patent number
US09382246B2

Reaction notes

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