Hydrochloric Acid → Hydrochloric Acid

HRID 1050508Notes

Reaction equation

HRID 1050508 reaction equation
[C:1]([C:4]1[N:9]=[N:8][C:7]([NH:10][C@@H:11]2[CH2:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)=[N:6][C:5]=1[NH:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)=[O:32])=[CH:27][CH:26]=1)(=[O:3])[NH2:2].[ClH:39]>O1CCOCC1>[N:33]1([C:31]([C:28]2[CH:29]=[CH:30][C:25]([NH:24][C:5]3[N:6]=[C:7]([NH:10][C@@H:11]4[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]4)[N:8]=[N:9][C:4]=3[C:1]([NH2:2])=[O:3])=[CH:26][CH:27]=2)=[O:32])[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1.[ClH:39]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 118114983US9656988, Example 60

Product 2

HCID 313Hydrochloric AcidHCID 118115044US9656988, Example 61

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(R)-tert-butyl 3-(6-carbamoyl-5-(4-(morpholine-4-carbonyl)phenylamino)-1,2,4-triazin-3-ylamino)piperidine-1-carboxylate (74) (180 mg) was treated with 4N HCl in dioxane (30 mL) at RT for 3 h. The mixture was concentrated in vacuo to yield the title compound (75) as HCl salt in quantitative yield. MS found C20H26N8O3 as (M+H)+ 427.1, (M−H)− 425.2. UV: λ=264, 283 nm.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-c05e837769074aebabfefa880907890d
Source dataset
uspto-grants-2016_07
Patent number
US09382246B2

Reaction notes

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