Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

(R)-tert-butyl 3-(6-carbamoyl-5-(4-(morpholine-4-carbonyl)phenylamino)-1,2,4-triazin-3-ylamino)pyrrolidine-1-carboxylate (82) (160 mg) was treated with 4N HCl in dioxane (30 mL) at RT for 3 h. The mixture was concentrated in vacuo to yield the title compound (83) as an HCl salt in quantitative yield. MS found C19H24N8O3 as (M+H)+ 413.1, (M−H)− 411.3. UV: λ=264, 283 nm.

Provenance & Evidence