Hydrochloric Acid → Hydrochloric Acid

HRID 1050511Notes

Reaction equation

HRID 1050511 reaction equation
[C:1]([C:4]1[N:9]=[N:8][C:7]([NH:10][C@@H:11]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)=[N:6][C:5]=1[NH:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)=[O:31])=[CH:26][CH:25]=1)(=[O:3])[NH2:2].[ClH:38]>O1CCOCC1>[N:32]1([C:30]([C:27]2[CH:28]=[CH:29][C:24]([NH:23][C:5]3[N:6]=[C:7]([NH:10][C@@H:11]4[CH2:15][CH2:14][NH:13][CH2:12]4)[N:8]=[N:9][C:4]=3[C:1]([NH2:2])=[O:3])=[CH:25][CH:26]=2)=[O:31])[CH2:33][CH2:34][O:35][CH2:36][CH2:37]1.[ClH:38]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 118115018HCID 118115018, compound

Product 2

HCID 313Hydrochloric AcidHCID 118114933HCID 118114933, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(R)-tert-butyl 3-(6-carbamoyl-5-(4-(morpholine-4-carbonyl)phenylamino)-1,2,4-triazin-3-ylamino)pyrrolidine-1-carboxylate (82) (160 mg) was treated with 4N HCl in dioxane (30 mL) at RT for 3 h. The mixture was concentrated in vacuo to yield the title compound (83) as an HCl salt in quantitative yield. MS found C19H24N8O3 as (M+H)+ 413.1, (M−H)− 411.3. UV: λ=264, 283 nm.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-23316439c0254615837d5faf21846f1d
Source dataset
uspto-grants-2016_07
Patent number
US09382246B2

Reaction notes

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