Potassium Carbonate → 3-Bromo-4-(3-hydroxypropoxy)benzonitrile

HRID 1050930Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[C:5]#[N:6].Br[CH2:12][CH2:13][CH2:14][OH:15].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH2:12][CH2:13][CH2:14][OH:15])[C:5]#[N:6]

Participants

Conditions

Temperature: 50 °C

Procedure

3-Bromo-4-hydroxy benzonitrile (10.0 g, 50.5 mmol) was dissolved in acetone and successively treated with 1-bromo-3-propanol (19.0 g, 138 mmol) and K2CO3 (20.9 g, 151 mmol) at ambient temperature. The resulting suspension was warmed to 50° C. and maintained 3 d. After cooling to ambient temperature, the solids were removed by filtration, exhaustively was with acetone and the filtrate concentrated. Purification by chromatography on SiO2 (A: hexanes; B: EtOAc; 0-100% B over 35.4 min; 200 mL/min; 330 g column) afforded a solid. Further purification by recrystallization from hot MTBE (131 mL) and pentane (130 mL), with cooling at −20° C. (12 h) to induce precipitation, afforded a solid (7.2 g, 58%). 1H NMR (300 MHz, CDCl3) δ 7.78 (s, 1H), 7.56 (d, J=9 Hz, 1H), 6.94 (d, J=6 Hz, 1H), 4.23 (t, J=6 Hz, 2H), 3.88 (t, J=6 Hz, 2H), 2.08 (m, J=6 Hz, 2H).

Workup

temperaturemaintained 3 d
temperatureAfter cooling to ambient temperature
customthe solids were removed by filtration
concentrationthe filtrate concentrated
customPurification by chromatography on SiO2 (A: hexanes
custom330 g column) afforded a solid
customFurther purification
customby recrystallization from hot MTBE (131 mL) and pentane (130 mL)
temperaturewith cooling at −20° C. (12 h)
customprecipitation

Sources & evidence

ORD record: ord-e911601b13fd4fa7b4d659da0cafbedf
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09388125B2

Reaction notes

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