HCID 178441573, compound → HCID 178441571, compound

HRID 1050945Notes

Reaction equation

[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:24][CH2:23][C@H:22]([NH:25]C(=O)[O-])[CH2:21][CH2:20]3)[CH2:13][CH2:12]2)[CH:8]=[C:7]([CH:29]2[CH2:32][CH2:31][CH2:30]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2]>Cl.C(OCC)(=O)C>[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:20][CH2:21][C@H:22]([NH2:25])[CH2:23][CH2:24]3)[CH2:15][CH2:16]2)[CH:8]=[C:7]([CH:29]2[CH2:32][CH2:31][CH2:30]2)[N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Conditions

Temperature: 25 °C

Procedure

Tert-butyl N-[trans-[4-[2-[4-(2-tert-butyl-6-cyclobutyl-pyrimidin-4-yl)piperazin-1-yl]ethyl]cyclohexyl]carbamate (11.20 g, 22.41 mmol) was dissolved in HCl/ethyl acetate (150 mL). The resulting solution was stirred at about 25° C. for 16 h. Solvent was removed under reduced pressure to provide the title compound (8.9 g, 21.16 mmol, 94% yield) as a colorless solid.

Workup

customSolvent was removed under reduced pressure

Sources & evidence

ORD record: ord-4da55b445e3f45e3b7bfd0d741d27e7e
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09388141B2

Reaction notes

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