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HRID1051131

反应详情

EQUATION

反应方程式

HRID 1051131 的结构方程式

REACTANTS

反应物

3
结构：c1cnc2c(c1)ccc1cccnc12
HCID1318

1,10-Phenanthroline

C12H8N2

结构：O=[N+]([O-])c1cnc(Br)c(C(F)(F)F)c1
HCID53486350

2-Bromo-5-nitro-3-(trifluoromethyl)pyridine

C6H2BrF3N2O2

结构：N#C[Cu]
HCID178418546

未命名化合物

PRODUCTS

生成物

1
结构：N#Cc1ncc([N+](=O)[O-])cc1C(F)(F)F
HCID21874893

5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrile

C7H2F3N3O2

收率 67%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)N(C)C
溶剂HCID31374

Dimethylacetamide

C4H9NO

CONDITIONS

反应条件

温度
160 °C

PROCEDURE

实验过程

The crude 2-bromo-5-nitro-3-(trifluoromethyl)pyridine 21 is dissolved in dimethylacetamide (DMA) and phenanthroline (0.2 equivalents) is added. The mixture is heated to 160° C. and CuCN (2 equivalents) is added. The mixture is stirred for 40 minutes. Chromatography is performed to produce the 5-nitro-3-(trifluoromethyl)pyridine-2-carbonitrile 22 in a yield of 67%.