1-Ethyl-4-(4-nitro-2-(trifluoromethyl)benzyl)piperazine → 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline

HRID 1051259Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051259
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:11]=2[C:19]([F:22])([F:21])[F:20])[CH2:5][CH2:4]1)[CH3:2]>[Pd].CO>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][C:11]=2[C:19]([F:22])([F:20])[F:21])[CH2:5][CH2:4]1)[CH3:2]

Komponenten

4

Edukt 1

HCID 576852631-Ethyl-4-(4-nitro-2-(trifluoromethyl)benzyl)piperazine

Produkt 1

HCID 591345644-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)anilineAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1-Ethyl-4-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (21.7 g, 68.3 mmol) obtained in Step (2) above was stirred in a solution of methanol. The reaction solution was mixed with Pd/C (1.8 g, 17.08 mmol), followed by stirring under hydrogen conditions for about 12 hours at room temperature. The reaction mixture was filtered through a Celite pad under reduced pressure, and washed with methanol. The filtrate was concentrated under reduced pressure to obtain the title compound (19.4 g, 99%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through a Celite pad under reduced pressure
  2. washwashed with methanol
  3. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-80192e7c7c6a4793bd9c29ab92766e25
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388165B2

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