Aniline → 1-(t-butylamino)-N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)isoquinoline-5-carboxamide

HRID 1051260Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051260
[C:1]([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:39]([N:41]1[CH2:46][CH2:45][N:44]([CH2:47]C2C=CC(N)=CC=2C(F)(F)F)[CH2:43][CH2:42]1)[CH3:40].NC1C=CC=CC=1>>[C:1]([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:32]=[CH:31][C:30]([CH2:47][N:44]5[CH2:45][CH2:46][N:41]([CH2:39][CH3:40])[CH2:42][CH2:43]5)=[C:29]([C:33]([F:34])([F:35])[F:36])[CH:28]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 6115AnilineHCID 591345644-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)anilineHCID 1180907961-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

Produkt 1

HCID 1180908191-(t-butylamino)-N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)isoquinoline-5-carboxamideAusbeute 12 %

Versuchsvorschrift

The procedures of Steps (1), (2) and (3) of Example 2 were repeated step by step, except for using 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline obtained in Step (3) above instead of aniline in Step (1) of Example 2 to obtain the title compound (0.032 g, 12%).

Quellen und Nachweise

ORD-Eintrag
ord-45f74da108814740978c62b10abfd2c6
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388165B2

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