HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 1-(t-butylamino)-N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)isoquinoline-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline | HCID 59134564 | — |
| Reactant | 1-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide | HCID 118090796 | — |
| Product | 1-(t-butylamino)-N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)isoquinoline-5-carboxamide | HCID 118090819 | 12% |
Reaction Steps
The procedures of Steps (1), (2) and (3) of Example 2 were repeated step by step, except for using 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline obtained in Step (3) above instead of aniline in Step (1) of Example 2 to obtain the title compound (0.032 g, 12%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388165B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-45f74da108814740978c62b10abfd2c6 |
| Source note | uspto-grants-2016_07 |