Aniline → 1-(t-butylamino)-N-(2-methyl-5-(phenylcarbamoyl)phenyl)isoquinoline-5-carboxamide

HRID 1051261Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051261
[C:1]([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29](C(F)(F)F)[CH:28]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2].NC1C=CC=CC=1>>[C:1]([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 6115AnilineHCID 1180907961-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

Produkt 1

HCID 1180908831-(t-butylamino)-N-(2-methyl-5-(phenylcarbamoyl)phenyl)isoquinoline-5-carboxamideAusbeute 3 %

Versuchsvorschrift

The procedures of Steps (1), (2) and (3) of Example 2 were repeated step by step, except for using aniline instead of 3-trifluoro-aniline in Step (1) of Example 2 to obtain the title compound (1.2 mg, 3%).

Quellen und Nachweise

ORD-Eintrag
ord-d225905776ff4b6e8f67410e46e36948
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388165B2

Notizen zur Reaktion

Wird geladen…