2-Amino-4-(trifluoromethyl)pyridine → 1-amino-N-(2-methyl-5-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)phenyl)isoquinoline-5-carboxamide

HRID 1051262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051262
C([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4C=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)(C)(C)C.[NH2:39]C1C=C(C(F)(F)F)C=CN=1>>[NH2:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:28]=[C:29]([C:33]([F:34])([F:35])[F:36])[CH:30]=[CH:31][N:39]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1

Komponenten

3

Edukt 2

HCID 27783152-Amino-4-(trifluoromethyl)pyridineHCID 1180907961-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

Produkt 1

HCID 1180908181-amino-N-(2-methyl-5-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)phenyl)isoquinoline-5-carboxamideAusbeute 7 %

Versuchsvorschrift

The procedures of Steps (1), (2) and (3) of Example 2 and Step (4) of Example 1 were repeated step by step, except for using 2-amino-4-(trifluoromethyl)pyridine instead of aniline in Step (1) of Example 2 to obtain the title compound (3.5 mg, 7%).

Quellen und Nachweise

ORD-Eintrag
ord-8f65152bf78e491d97b231723a164401
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388165B2

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