HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-(trifluoromethyl)pyridine → 1-amino-N-(2-methyl-5-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)phenyl)isoquinoline-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-(trifluoromethyl)pyridine | HCID 2778315 | — |
| Reactant | 1-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide | HCID 118090796 | — |
| Product | 1-amino-N-(2-methyl-5-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)phenyl)isoquinoline-5-carboxamide | HCID 118090818 | 7% |
Reaction Steps
The procedures of Steps (1), (2) and (3) of Example 2 and Step (4) of Example 1 were repeated step by step, except for using 2-amino-4-(trifluoromethyl)pyridine instead of aniline in Step (1) of Example 2 to obtain the title compound (3.5 mg, 7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388165B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-8f65152bf78e491d97b231723a164401 |
| Source note | uspto-grants-2016_07 |