4-Chloroaniline → N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

HRID 1051277노트

반응식

HRID 1051277 반응식
NC1C2C=CC=C(C([NH:14][C:15]3[C:24]([CH3:25])=[CH:23][CH:22]=[C:21]4[C:16]=3[CH:17]=[CH:18][N:19]=[C:20]4[NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[C:29](C(F)(F)F)[CH:28]=3)=O)C=2C=CN=1.[Cl:37]C1C=CC(N)=CC=1>>[Cl:37][C:30]1[CH:31]=[CH:32][C:27]([NH:26][C:20]2[C:21]3[CH:22]=[CH:23][C:24]([CH3:25])=[C:15]([NH2:14])[C:16]=3[CH:17]=[CH:18][N:19]=2)=[CH:28][CH:29]=1

참가 물질

3

반응물 2

HCID 78124-ChloroanilineHCID 1180907981-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)isoquinoline-5-carboxamide

생성물 1

HCID 44478904N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine수율 50%

실험 절차

The procedures of Steps (1) and (2) of Example 18 were repeated step by step, except for using 4-chloroaniline instead of aniline in Step (1) of Example 18 to obtain the title compound (0.83 g, 50%).

출처 및 근거

ORD 기록
ord-6d5b87c2e6794341bbcaa70ec41a37f3
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388165B2

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