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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1051277Generated: October 26, 2026

4-Chloroaniline → N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

https://huagongshe.com/reaction/1051277

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChloroanilineHCID 7812—
Reactant1-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)isoquinoline-5-carboxamideHCID 118090798—
ProductN1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamineHCID 4447890450%

Reaction Steps

The procedures of Steps (1) and (2) of Example 18 were repeated step by step, except for using 4-chloroaniline instead of aniline in Step (1) of Example 18 to obtain the title compound (0.83 g, 50%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09388165B2
Source datasetuspto-grants-2016_07
ORD IDord-6d5b87c2e6794341bbcaa70ec41a37f3
Source noteuspto-grants-2016_07