HCID 118555065, compound → HCID 118555043, compound

HRID 1051287Notes

Reaction equation

HRID 1051287 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH2:15][CH:16]([CH3:18])[CH3:17])[C:9]#[N:10])[CH:5]=[CH:4][N:3]=[CH:2]1.C(O)(=[S:21])C>C(O)(=O)C>[N:1]1([C:6]2[CH:7]=[C:8]([C:9](=[S:21])[NH2:10])[CH:11]=[CH:12][C:13]=2[O:14][CH2:15][CH:16]([CH3:18])[CH3:17])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 118555065HCID 118555065, compoundHCID 178418634HCID 178418634, compound

Product 1

HCID 118555043HCID 118555043, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

A reaction mixture prepared by suspending the crude product of 3-(1H-imidazol-1-yl)-4-(2-methylpropoxy)benzonitrile obtained above in a mixture of 0.2 mL of acetic acid and 0.5 mL of thioacetic acid was heated at 50° C. for 14 hours under a nitrogen atmosphere. Concentration under reduced pressure was prepared to obtain a crude product of 3-(1H-imidazol-1-yl)-4-(2-methylpropoxy)benzene-1-carbothioamide.

Workup

  1. customA reaction mixture prepared
  2. concentrationConcentration under reduced pressure
  3. customwas prepared

Sources & evidence

ORD record
ord-27904115b5684fffb319721bf728e1e7
Source dataset
uspto-grants-2016_07
Patent number
US09388174B2

Reaction notes

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