Hydrochloric Acid → 2-(5-Piperidin-4-yl-4h-1,2,4-triazol-3-yl)-pyridine dihydrochloride

HRID 1051312Notes

Reaction equation

HRID 1051312 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[NH:11][N:10]=[C:9]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[N:8]=1.[ClH:25]>CO.O1CCOCC1>[ClH:25].[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12]([C:9]2[N:8]=[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[NH:11][N:10]=2)[CH2:13][CH2:14]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178451825HCID 178451825, compound

Product 1

HCID 1784785342-(5-Piperidin-4-yl-4h-1,2,4-triazol-3-yl)-pyridine dihydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 4-[5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl]piperidine-1-carboxylate 39 g (111 mM) in methanol 50 is added 100 ml solution of HCl in dioxane and stirred at room temperature for 3 hrs. Solid precipitated is then filtered and washed with cold acetonitrile to obtained 2-[3-(piperidin-4-yl)-1H-1,2,4-triazol-5-yl]pyridine dihydrochloride as white solid.

Workup

  1. customSolid precipitated
  2. filtrationis then filtered
  3. washwashed with cold acetonitrile

Sources & evidence

ORD record
ord-0dddb70eabd74b4994987cad94dff3bf
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

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