Hydrazine hydrate (1:1) → 1H-pyrrole-2-carbohydrazonamide

HRID 1051313Notes

Reaction equation

HRID 1051313 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].O.[NH2:12][NH2:13]>C(O)C.O>[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:12][NH2:13])[NH2:7]

Participants

6

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 138277Pyrrole-2-carbonitrileHCID 10942334Sodium Methoxide

Product 1

HCID 1363872481H-pyrrole-2-carbohydrazonamide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 1H-pyrrole-2-carbonitrile 10 g (108 mM) and sodium methoxide (1 eq) in ethanol (20 ml) and stirred for 10 min. Hydrazine hydrate (3 eq.) is then added and resulting reaction mixture is stirred at room temperature for 18 hrs. Reaction mass is then diluted with water, extracted with ethyl acetate, dried over anhydrous sodium sulphate and concentrated under vacuum to yield desired compound.

Workup

  1. customresulting
  2. customreaction mixture
  3. customReaction mass
  4. extractionextracted with ethyl acetate
  5. dry with materialdried over anhydrous sodium sulphate
  6. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-5c6bda43947d4a8391dd3a6cbf3b28b5
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

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