Hydrogen chloride-ethyl acetate → HCID 14689279, compound

HRID 1051485Notes

Reaction equation

HRID 1051485 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][CH:12]([OH:29])[CH2:13][O:14][C:15]1[CH:16]=[C:17]([NH:21]C(=O)OC(C)(C)C)[CH:18]=[CH:19][CH:20]=1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[NH2:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[O:14][CH2:13][CH:12]([OH:29])[CH2:11][N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86729264HCID 86729264, compound

Product 1

HCID 14689279HCID 14689279, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl (3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropoxy)phenyl)carbamate (1.2 g, 3.01 mmol) in ethyl acetate (30 mL) was added HCl/ethyl acetate (20 mL). The reaction mixture was stirred at room temperature for 2 h. and the concentrated with the residue used in the next step without further purification.

Workup

  1. concentrationthe concentrated with the residue
  2. customused in the next step without further purification

Sources & evidence

ORD record
ord-f99364bb721544b9b713db57a1eac618
Source dataset
uspto-grants-2016_07
Patent number
US09388173B2

Reaction notes

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