HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1051532Generated: November 2, 2026
Potassium Carbonate → HCID 4189043, compound
https://huagongshe.com/reaction/1051532
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 8-Bromoquinoline | HCID 140109 | — |
| Reactant | (3-Methoxyphenyl)boronic acid | HCID 2734370 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | HCID 4189043 | HCID 4189043 | 90% |
Reaction Steps
To a solution of 8-bromoquinoline (208.05 mg, 1.0 mmol) in dioxane/H2O (10 mL) was added (3-methoxyphenyl)boronic acid (182.3 mg, 1.2 mmol), Pd(dppf)Cl2 (100 mg) and K2CO3 (276 mg, 2 mmol). The reaction mixture was heated at 120° C. under microwave conditions for 30 minutes before cooling and being concentrated to remove the solvents. The residue was dissolved in ethyl acetate, washed with water and the separated organic layer concentrated to yield a crude product which was used in next step without further purification. (312 mg, Yield 90%). LCMS (m/z): 236.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09388173B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-d68f34c0ee7d429f98744c28731b45ab |
|---|
| Source note | uspto-grants-2016_07 |
|---|
