HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-8-Fluoro-5-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline → (S)-(6-Bromo-8-fluoro-5-hydroxy-2-methyl-3,4-dihydroquinolin-1 (2H)-yl)(cyclopropyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-8-Fluoro-5-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline | HCID 118075452 | — |
| Reactant | (2S)-6-bromo-1-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinolin-5-ol | HCID 118075707 | — |
| Product | (S)-(6-Bromo-8-fluoro-5-hydroxy-2-methyl-3,4-dihydroquinolin-1 (2H)-yl)(cyclopropyl)methanone | HCID 118086471 | — |
Reaction Steps
(S)-(6-Bromo-8-fluoro-5-hydroxy-2-methyl-3,4-dihydroquinolin-1 (2H)-yl)(cyclopropyl)methanone was synthesized from (S)-8-fluoro-5-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline according to the procedures described above for (2S)-6-bromo-1-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinolin-5-ol (Intermediate 2, Steps 1a, 2a, and 3). MS (ESI, pos. ion) m/z 328, 330 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388161B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-18a37901c48c483b8fb57f5a1dd7d23d |
| Source note | uspto-grants-2016_07 |