反应详情

Methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate (5.8 g, 23.5 mmol), prepared from methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate according to the process of WO 10/122578, was refluxed in the solution of NaOH (1.88 g, 46.9 mmol) in MeOH (40 mL) and water (20 mL) overnight. After the completion of the reaction, the MeOH was evaporated and 80 mL of water was added. The pH of the solution was adjusted to 8 by addition of 6M HCl and the resulting white precipitate was filtered off and dried overnight in an oven at 100° C. to afford 3.5 g of (±)-Ia.

1. customAfter the completion of the reaction
2. customthe MeOH was evaporated
3. addition80 mL of water was added
4. additionThe pH of the solution was adjusted to 8 by addition of 6M HCl
5. filtrationthe resulting white precipitate was filtered off
6. customdried overnight in an oven at 100° C.
7. customto afford 3.5 g of (±)-Ia