反应详情

The roughly purified product of Intermediate 37 (142 g) was reduced by hydrogenation at room temperature for 9 hours by using 10% Pd/C (7.1 g) and ethyl acetate solution (1.42 l) under hydrogen atmosphere of 1 atm. The palladium catalyst was removed by filtration, and the solvent was evaporated under reduced pressure. Then, the residue was purified by flash column chromatography (chloroform:methanol:triethylamine=100:20:10) to obtain the title compound (45.8 g).

1. customThe palladium catalyst was removed by filtration
2. customthe solvent was evaporated under reduced pressure
3. customThen, the residue was purified by flash column chromatography (chloroform:methanol:triethylamine=100:20:10)