2-Amino-5-bromopyridine → Ethyl [(5-bromopyridin-2-yl)carbamothioyl]carbamate

HRID 1051846Notes

Reaction equation

HRID 1051846 reaction equation
[CH2:1]([O:3][C:4]([N:6]=[C:7]=[S:8])=[O:5])[CH3:2].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][N:11]=1>O1CCOCC1>[Br:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:7]([NH:6][C:4](=[O:5])[O:3][CH2:1][CH3:2])=[S:8])=[N:11][CH:12]=1

Participants

4

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 85320Ethyl isothiocyanatoformate

Product 1

HCID 59286274Ethyl [(5-bromopyridin-2-yl)carbamothioyl]carbamate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Ethoxycarbonylisothiocyanate (16.7 g) was added to a stirred solution of 2-amino-5-brompyridine (20 g) in dioxane (200 mL). The mixture was stirred for 2 h at r.t. A white solid precipitated. Hexane (20 mL) was added and the white solid was collected by filtration.

Workup

  1. customA white solid precipitated
  2. additionHexane (20 mL) was added
  3. filtrationthe white solid was collected by filtration

Sources & evidence

ORD record
ord-cd99124a9ea24b0a9acfe666ea2dcbab
Source dataset
uspto-grants-2016_07
Patent number
US09388177B2

Reaction notes

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