Pyrrolidine → (4-Bromo-3-methoxyphenyl)(pyrrolidin-1-yl)methanone

HRID 1051853Notes

Reaction equation

HRID 1051853 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[O:11][CH3:12].[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[O:8])=[CH:4][C:3]=1[O:11][CH3:12]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 162158674-Bromo-3-methoxybenzoic acid

Product 1

HCID 71412413(4-Bromo-3-methoxyphenyl)(pyrrolidin-1-yl)methanone

Procedure

Starting with 4-bromo-3-methoxybenzoic acid and pyrrolidine, Int02.07 was prepared analogously to the procedure for the preparation of Int02.04.

Workup

  1. customwas prepared analogously to the procedure for the preparation of Int02.04

Sources & evidence

ORD record
ord-552658d35b224dd4a9bce653467c5ae3
Source dataset
uspto-grants-2016_07
Patent number
US09388177B2

Reaction notes

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