Pyrrolidine → HCID 89633439, compound

HRID 1051862Notes

Reaction equation

HRID 1051862 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14].[NH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:8])=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 59581703HCID 59581703, compound

Product 1

HCID 89633439HCID 89633439, compound

Procedure

Starting with 4-bromo-3-(2,2,2-trifluoroethoxy)benzoic acid and pyrrolidin, Int06.06 was prepared analogously to the procedure for the preparation of Int02.05.

Workup

  1. customwas prepared analogously to the procedure for the preparation of Int02.05

Sources & evidence

ORD record
ord-bf59d8feded44c1c9dff29bdb521de81
Source dataset
uspto-grants-2016_07
Patent number
US09388177B2

Reaction notes

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