HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 2-Phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Methyl 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate | HCID 90303482 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 2-Phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid | HCID 90303378 | — |
Reaction Steps
A mixture of methyl 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (12.0 mg, 0.044 mmol) and LiOH.H2O (2.7 mg, 0.065 mmol) in THF/MeOH/H2O (1 mL, 3:1:1) was stirred at RT for 45 min. The mixture was acidified to pH=3 and extracted with DCM. The comb. org. layers were dried over MgSO4, and conc. in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388197B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-ad6a866ce8264dd5b9b1a2f2ab32d3fa |
| Source note | uspto-grants-2016_07 |