Lithium hydroxide, monohydrate → HCID 84710731, compound

HRID 1051919Notes

Reaction equation

HRID 1051919 reaction equation
[Br:1][C:2]1[S:3][C:4]2[CH:10]([C:11]([O:13]C)=[O:12])[CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1.O[Li].O>C1COCC1.CO.O.O>[Br:1][C:2]1[S:3][C:4]2[CH:10]([C:11]([OH:13])=[O:12])[CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 84714393HCID 84714393, compound

Product 1

HCID 84710731HCID 84710731, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

A mixture of methyl 2-bromo-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (150 mg, 0.54 mmol) and LiOH.H2O (34 mg, 0.81 mmol) in THF/MeOH/H2O (5 mL, 3:1:1) was stirred at RT for 90 min. The mixture was diluted with H2O and extracted with DCM. The aq. layer was acidified to pH=3 and extracted with DCM. The comb. org. layers were washed with brine, dried over MgSO4, and conc. in vacuo.

Workup

  1. extractionextracted with DCM
  2. extractionextracted with DCM
  3. washlayers were washed with brine
  4. dry with materialdried over MgSO4

Sources & evidence

ORD record
ord-c9bd8137951c49bfacc6127e6a298eb5
Source dataset
uspto-grants-2016_07
Patent number
US09388197B2

Reaction notes

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