Phthalimide → 2,4-Dichloro-6-cyclopropylbenzylamine

Participants

Reaction Conditions

Reaction Steps

A.2.1.1. Synthesis of 2-(2-bromo-4,6-dichlorobenzyl)isoindoline-1,3-dione To a soln. of 1-bromo-2-(bromomethyl)-3,5-dichlorobenzene (1.98 mmol) [J. Med. Chem. 1992, 35, 4221-4229] in 10 mL CH3CN were added phthalimide (1.98 mmol) and K2CO3 (5.93 mmol). The reaction mixture was stirred at 50° C. for 6 h and then at RT overnight. Sat. aq. NaHCO3 soln. was added and the mixture was extracted 3 times with DCM. The comb. org. phases were dried over MgSO4 and conc. in vacuo to obtain the desired product as beige solid.

Provenance & Evidence