反应详情

温度

50 °C

A.2.1.1. Synthesis of 2-(2-bromo-4,6-dichlorobenzyl)isoindoline-1,3-dione To a soln. of 1-bromo-2-(bromomethyl)-3,5-dichlorobenzene (1.98 mmol) [J. Med. Chem. 1992, 35, 4221-4229] in 10 mL CH3CN were added phthalimide (1.98 mmol) and K2CO3 (5.93 mmol). The reaction mixture was stirred at 50° C. for 6 h and then at RT overnight. Sat. aq. NaHCO3 soln. was added and the mixture was extracted 3 times with DCM. The comb. org. phases were dried over MgSO4 and conc. in vacuo to obtain the desired product as beige solid.

1. customat RT
2. customovernight
3. additionwas added
4. extractionthe mixture was extracted 3 times with DCM
5. dry with materialphases were dried over MgSO4 and conc. in vacuo